Legends of Runeterra is a strategy card game that relies on skill rather than luck. Players can mix and match champions, allies, and regions of Runeterra to unlock unique card synergies and outplay their opponents. The game features dynamic, alternating gameplay that allows players to react and counter their opponents. Players can choose from dozens of champion cards, each with a different mechanic inspired by their original League of Legends abilities. Champions enter the battle as powerful cards, and if played smartly, they level up to become even more epic.

The game features nine regions of Runeterra, and every champion and ally in the game comes from one of these regions. Players can explore how different champions and regions work together to give them unique advantages against their opponents. The game is always evolving, with frequent new releases that allow players to combine, adapt, and experiment with different strategies.

Players can earn cards for free or buy exactly what they want with shards and wildcards. The game is designed to be played to win, not pay to win. Victory or defeat in each battle brings experience and progress, and players can choose which region they explore first and unlock the cards that call to them. Once a week, players can unlock chests from the Vault, which level up the more they play, increasing the rarity of cards inside from common all the way up to champion.

In addition to the classic Legends of Runeterra formula, the game features limited-time experimental game modes called Labs. Players can choose a premade deck with specific constraints or bring their own. The rules are always changing, and sometimes players might need a little help from their friends. The game also features Ranked play, where players can climb the ranks and compete for pride, glory, and a cash prize in the seasonal tournament.